GHK-Cu may Prevent Oxidative Stress in Skin by Regulating Copper and Modifying Expression of Numerous Antioxidant Genes Loren Pickart, Jessica Michelle Vasquez-Soltero, and Anna Margolina Skin Biology, Research & Development Department, 4122 Factoria Boulevard SE, Suite No. 200, Bellevue, WA 98006, USA Received: 17 June 2015 / Accepted: 21 July 2015 / Published: 28 July 2015
The copper binding tripeptide GHK (glycyl-l-histidyl-l-lysine) is a naturally occurring plasma peptide that significantly declines during human aging. It has been established that GHK:Copper(2+) improves wound healing and tissue regeneration and stimulates collagen and decorin production. GHK-Cu also improves the condition of aging skin and hair, and possesses antioxidant and anti-inflammatory effects. In addition, it increases cellular stemness and secretion of trophic factors by mesenchymal stem cells. GHK’s antioxidant actions have been demonstrated in vitro and in animal studies. They include blocking the formation of reactive oxygen and carbonyl species, detoxifying toxic products of lipid peroxidation such as acrolein, protecting keratinocytes from lethal Ultraviolet B (UVB) radiation, and blocking hepatic damage by dichloromethane radicals. This paper reviews biological data demonstrating positive effects of GHK in skin and proposes interaction with antioxidant related genes as a possible explanation of its antioxidant activity.
One of the most common experiences people report with the X39® patch is an improvement in energy levels. When the energy patches were first developed in 2002, and then first sold in 2004, it was established with multiple clinical studies that the Energy patches were upregulating which is known as beta oxidation (fat burning) by around 23%. As the body derives more energy from fat than carbohydrates, it was easy to see why people were reporting the feelings of more energy.
The Aeon patch was released in 2011, and this patch was designed to reduce inflammation and increase antioxidant production with the benefit of providing stress relief. People that use Aeon often report feeling calmer during the day as well as having more energy from this stress reduction.
It is hypothesized at this point based on the data we have that the X39® is increasing the feeling of energy that people have through the reduction of inflammation, oxidative stress, and elevation of antioxidants. As we know that GHK-Cu provides these benefits, and we know that inflammation and
oxidative stress reduce a persons energy capacity, this is a reasonable conclusion. In the future, there may be studies that look at this specific benefit of the X39® patch. As of December 2018, a clinical study completed by Dr. Thornton Streeter did in fact demonstrate that continued use of the X39® patch resulted in an overall improvement of a person’s energy levels. As a review, following is what LifeWave has substantiated by its own clinical research as the benefits that come from wearing the X39® patch on a regular basis:
WOUND HEALING – Some of our most dramatic testimonial on the X39® have been in the area of wound healing. Wound healing is of course a natural process and requires the presence of stem cells. As we age, our stem cells become less effective though. Now, with X39®, you can activate you stem cells and provide support for your body’s natural healing process.
RAPID PAIN RELIEF – X39® users can experience dramatic reductions in pain. In fact, most people experience a reduction in the sensation of pain and inflammation within minutes of application.
GREATER ENERGY – Clinical studies performed by LifeWave show that the X39® patch improved a person’s energy levels. The results when compared to the baseline, see the improvement in overall energy of the body, organ balance, and L/R symmetry distribution of energy.
SLEEP BENEFITS – Clinical studies performed by LifeWave show that X39® improves the quality of sleep by altering levels of GABA, an important neurotransmitter in the brain. The benefit is a natural improvement in your quality and duration of sleep.
IMPROVED SKIN APPEARANCE – Would you like to not only feel younger but look younger as well? Now you can with X39®. An important part of activating stem cells is increasing the production of collagen. The result is that only a few weeks after applying X39® your skin will start to experience a significant reduction in the appearance of lines and wrinkles.
DRAMATIC ANTI-AGING – Initial clinical work performed by Dr. Loren Pickart, it was shown that when GHK-Cu is elevated in the body, we can see that cells start to behave like younger, healthier cells. Essentially helping to restore our cells to a younger state.
FASTER RECOVERY FROM EXERCISE – Users of X39® report significant improvements in their sports
performance and recovery. As stem cells are designed to repair damaged cells, this is not surprising.
REDUCED INFLAMMATION – Many users of X39® report that after several weeks of using the product, they notice a reduction in the appearance of scars. This is a well-known attribute of elevating copper peptide known as remodeling.